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Cat.:P0004Rb-r
Packing:40ug/0.2ml
Gene name:Ace(Dcp1);
Protein name:Angiotensin-converting enzyme(ACE);
Alternative: Dipeptidyl carboxypeptidase I;Kininase II;
CD: CD143;
Organism:Rat (Rattus norvegicus).
General Annotation
Sub Unit:N/A
Function:Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm.
Subcellular Location: Cell membrane Single-pass type I membrane protein
Protein Attributes:
Sequence length:1313
Sequence:
50:MGAASGQRGR | WPLSPPLLML | SLLLLLLLPP | SPAPALDPGL | QPGNFSADEA |
100:GAQLFADSYN | SSAEVVMFQS | TAASWAHDTN | ITEENARLQE | EAALINQEFA |
150:EVWGKKAKEL | YESIWQNFTD | QKLRRIIGSV | QTLGPANLPL | TQRLQYNSLL |
200:SNMSRIYSTG | KVCFPNKTAT | CWSLDPELTN | ILASSRNYAK | VLFAWEGWHD |
250:AVGIPLRPLY | QDFTALSNEA | YRQDGFSDTG | AYWRSWYESP | SFEESLEHLY |
300:HQVEPLYLNL | HAFVRRALHR | RYGDKYINLR | GPIPAHLLGD | MWAQSWENIY |
350:DMVVPFPDKP | NLDVTSTMVQ | KGWNATHMFR | VAEEFFTSLG | LSPMPPEFWA |
400:ESMLEKPADG | REVVCHASAW | DFYNRKDFRI | KQCTRVTMDQ | LSTVHHEMGH |
450:VQYYLQYKDL | HVSLRRGANP | GFHEAIGDVL | ALSVSTPAHL | HKIGLLDRVA |
500:NDIESDINYL | LKMALEKIAF | LPFGYLVDQW | RWGVFSGRTP | PSRYNYDWWY |
550:LRTKYQGICP | PVARNETHFD | AGAKFHIPSV | TPYIRYFVSF | VLQFQFHQAL |
600:CKEAGHQGPL | HQCDIYQSTK | AGAKLQQVLQ | AGCSRPWQEV | LKDLVGSDAL |
650:DASALMEYFQ | PVSQWLQEQN | QRNGEVLGWP | EYQWRPPLPD | NYPEGIDLET |
700:DEAKANRFVE | EYDRTAKVLW | NEYAEANWHY | NTNITIEGSK | ILLQKNKEVS |
750:NHTLKYGTWA | KTFDVSNFQN | STIKRIIKKV | QNVDRAVLPP | NELEEYNQIL |
800:LDMETTYSVA | NVCYTNGTCL | SLEPDLTNIM | ATSRKYEELL | WVWKSWRDKV |
850:GRAILPFFPK | YVDFSNKIAK | LNGYSDAGDS | WRSSYESDDL | EQDLEKLYQE |
900:LQPLYLNLHA | YVRRSLHRHY | GSEYINLDGP | IPAHLLGNMW | AQTWSNIYDL |
950:VAPFPSAPSI | DATEAMIKQG | WTPRRIFKEA | DNFFTSLGLL | PVPPEFWNKS |
1000:MLEKPTDGRE | VVCHASAWDF | YNGKDFRIKQ | CTSVNMEELV | IAHHEMGHIQ |
1050:YFMQYKDLPV | TFREGANPGF | HEAIGDVLAL | SVSTPKHLHS | LNLLSSEGSG |
1100:YEHDINFLMK | MALDKIAFIP | FSYLIDQWRW | RVFDGSITKE | NYNQEWWSLR |
1150:LKYQGLCPPV | PRSQGDFDPG | SKFHVPANVP | YIRYFISFII | QFQFHEALCR |
1200:AAGHTGPLYK | CDIYQSKEAG | KLLADAMKLG | YSKQWPEAMK | IITGQPNMSA |
1250:SAIMNYFKPL | TEWLVTENRR | HGETLGWPEY | TWTPNTARAE | GSLPESSRVN |
1300:FLGMYLEPQQ | ARVGQWVLLF | LGVALLVATV | GLAHRLYNIH | NHHSLRRPHR |
1313:GPQFGSEVEL | RHS
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